Microbiology Final (Research Project) Research Paper

Microbiology Final ( Project) - investigate Paper ExampleExcluding the Reston subtype of Ebola virus, all other types cause infection in the humans (Reddy 2002). The virus was determine initially in the year 1967 in Marburg, Germany after the presence of this virus was seen in workers of a laboratory. This was owe to their continuous contact with monkeys in the laboratory (Carruthers et al 2005).Ebola viruses are morphologically classified as collar viral particles which show pleomorphism in their shapes. It can be long, filamentous or in philippic forms. The dimensions of the virus are length of 14,000 nm and diameter of 80nm, encompassed in a membrane composed of lipoid molecules. Ebola is a single-stranded RNA virus and it multiplies by the process of asexual reproduction, budding. Ebola virus consists of seven structural and one non-structural protein. Nucleoprotein is the major structural protein and others include virion structural protein (VP) 30, VP 35 and large protei n (L) (Georgiev 2009). Ebola viruss rude(a) habitat is still not completely know by the microbiologists but it has, however, been established that Ebola virus is an animal-borne or zoonotic virus. Therefore, it maintains its natural reservoirs in animal hosts (Reddy 2002).Ebola life cycle initiates with the entry of the virus into different types of cells through the viral surface glycoprotein which regulate the entry of the virus. Figure 1 provides an overview of the entry of the virus into the host cell. accredited receptors on the cell surfaces promote the entry of the virus and render them vulnerable to the attack of the virus. These receptors include folic acid receptor-a, proteins of C-type lectin family and L-SIGN receptors expressed on Jurkat cells, macrophages and endothelial cells respectively. Once, binding and fusion of the virus in the cells is complete, the viral genome is uncoated. However, little is known about this process. The